Phenytoin monograph bnf
WebUSP Monographs: Phenytoin Phenytoin C 15 H 12 N 2 O 2 252.27 2,4-Imidazolidinedione, 5,5-diphenyl-. 5,5-Diphenylhydantoin [ 57-41-0 ]. » Phenytoin contains not less than 98.0 percent and not more than 102.0 percent of C 15 H 12 N 2 O 2, calculated on the dried basis. Packaging and storage— Preserve in tight containers. WebPHENYTOIN SODIUM INJECTION USP is indicated for the control of generalized tonic- clonic status epilepticus, and for the prevention and treatment of seizures occurring during …
Phenytoin monograph bnf
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Web2. feb 2024 · 1. Name of the medicinal product 2. Qualitative and quantitative composition 3. Pharmaceutical form 4. Clinical particulars 5. Pharmacological properties 6. Pharmaceutical particulars 7. Marketing authorisation holder 8. Marketing authorisation number (s) 9. Date of first authorisation/renewal of the authorisation 10. Date of revision of the text WebWorld Health Organization
Web1. apr 2024 · Phenytoin thereby reduces the over-activity of brain stem centres responsible for the tonic phase of grand mal seizures. Phenytoin sodium's antiarrhythmic action may be attributed to the normalization of influx of sodium and calcium to cardiac Purkinje fibres. Abnormal ventricular automaticity and membrane responsiveness are decreased. WebCorrected phenytoin (mg/L)= Observed phenytoin (mg/L) (O.2 x albumin [g/dL]) + 0.1 In end-stage renal failure patients, the binding of phenytoin to albumin is impaired. Thus, the …
WebPhenytoin is predicted to decrease the exposure to Maribavir. Manufacturer advises avoid or adjust Maribavir dose. Severity: Severe Evidence: Study Primidone Primidone is predicted to decrease the exposure to Maribavir. Manufacturer advises avoid or adjust Maribavir dose. Severity: Severe Evidence: Study Rifabutin Prevention and treatment of seizures during or following neurosurgery or severe head injury. By mouth. Child. Initially 2.5 mg/kg twice daily, then adjusted according to response to 4–8 mg/kg daily, dose also adjusted according to plasma-phenytoin concentration; maximum 300 mg per day. Zobraziť viac Symptoms of phenytoin toxicity include nystagmus, diplopia, slurred speech, ataxia, confusion, and hyperglycaemia. Zobraziť viac Rash Discontinue; if mild re-introduce cautiously but discontinue immediately if recurrence. Bradycardia and hypotension With intravenous use; reduce rate of administration if … Zobraziť viac
WebAcute alcoholic intake may increase phenytoin serum levels while chronic alcoholic use may decrease serum levels. Phenytoin is not indicated for seizures due to hypoglycemic or other metabolic causes. Appropriate diagnostic procedures should be performed as indicated. Phenytoin is not effective for absence (petit mal) seizures.
WebAbsorption. Given its narrow therapeutic index, therapeutic drug monitoring is recommended to help guide dosing. 8,10 Phenytoin is completely absorbed. 8 Peak plasma concentration is attained approximately 1.5-3 hours, and 4-12 hours after administration of the immediate release formulation and the extended release formulation, respectively. 3,8 It should be … helplessly hoping fingerstyle tabWeb18. okt 2024 · Phenytoin (Monograph) Brand names: Dilantin, Dilantin Infatabs, Phenytek Drug class: Hydantoins VA class: CN400 CAS number: 57-41-0 Medically reviewed by Drugs.com on Oct 18, 2024. Written by ASHP. Introduction Uses Dosage Warnings Interactions Stability Warning Cardiovascular Risk Associated with Rapid IV Administration helplessly hoping girl named tom chordsWebBlood, hepatic, or skin disorders. Carbamazepine should be withdrawn immediately in cases of aggravated liver dysfunction or acute liver disease. Leucopenia that is severe, … helplessly hoping fingerpicking