WebHistone H2A variants generate diversity in chromatin structure and functions, as nucleosomes containing variant H2A histones have altered physical, chemical, and biological properties. H2A.Z is an evolutionarily ancient and highly conserved H2A variant that regulates processes ranging from gene expression to the DNA damage response. WebApr 1, 2002 · Several of the variants differ from the consensus sequence at many positions throughout the sequence, whereas one, H2AX, differs primarily in the carboxyl terminus. Two variants, H2AX and H2AZ, are highly conserved as unique H2A species from S. cerevisiae to human. The macroH2A species may have arisen more recently in evolution …
Histone Variants Database 2.0
WebAug 13, 2014 · Histone H2A.Z (H2A.Z) is an evolutionarily conserved H2A variant implicated in the regulation of gene expression; however, its role in transcriptional deregulation in cancer remains poorly understood. physiotherapeut steyr
Connection between histone H2A variants and chromatin …
WebOct 1, 2024 · These variants all derive from a single gene on the X chromosome of a common ancestor and have since diverged into four distinct clades known as H2A.P, H2A.Q, H2A.B, and H2A.L . The H2A.P-encoding gene had the previously approved symbol HYPM for “huntingtin interacting protein M” and has now been renamed as H2AP for … WebH2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and … WebUnder nitrogen-starvation condition, TORC1 is inactivated, leading to reduced activity of Rpd3L complex and increased acetylation of Ino80 and H2A.Z, which in turn induce the transcription of ATG genes. These results reveal a critical role of chromatin remodelers and histone variants in regulating autophagy in response to nutrient availability. physiotherapeut stralsund