Web1 phenotype from 1 allele in 1 genetic background 6 phenotypes from multigenic genotypes 7 phenotype references Phenotype Overview Blue squares indicate phenotypes directly … WebMar 28, 2024 · But, HMMR is an intracellular, microtubule-associated, spindle assembly factor that localizes protein complexes to augment the activities of mitotic kinases, like polo-like kinase 1 and Aurora kinase A, and control dynein and kinesin motor activities. Expression of HMMR is elevated in cells prior to and during mitosis and tissues with ...
Dynein assembly factor with WD repeat domains 1 (DAW1) is ... - PubMed
WebMar 4, 2012 · Abstract. Primary ciliary dyskinesia most often arises from loss of the dynein motors that power ciliary beating. Here we show that DNAAF3 (also known as PF22), a previously uncharacterized protein, is essential for the preassembly of dyneins into complexes before their transport into cilia. We identified loss-of-function mutations in the … Webdynein assembly factor 4, axonemal, dyslexia susceptibility 1 candidate 1. GeneRIFs: Gene References Into Functions. DYX1C1 is required for axonemal dynein assembly and ciliary motility. In dyx1c1 morphants, cilia length is reduced in several organs including Kupffer's vesicle, pronephros, spinal canal and olfactory placode. ... dungeness crab boil time
Condensation of pericentrin proteins in human cells illuminates …
WebNon-lethal low levels of oxidative stress leads to rapid activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which upregulates the expression of genes important for detoxification, glutathione synthesis, and defense against oxidative damage. Stress-activated MAP kinases p38, ERK, and JNK cooperate in the efficient nuclear … WebNX_Q8NEP3 - DNAAF1 - Dynein axonemal assembly factor 1 - Function. Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli. WebJul 7, 2024 · Endogenously GFP-tagged PCNT forms dynamic aliphatic alcohol-sensitive pericentrosomal granules during late G2/early M phases. To study full-length PCNT at endogenous levels in cells, we used CRISPR technology (Lin et al., 2014a; Zhang et al., 2024) to insert super-folder GFP sequence into the 5′ end of the PCNT locus in hTERT … dungeness crab boil or steam