WebAt the transcription level, CDH6 was significantly overexpressed in ovarian cancer tissues (P < 0.05). Although it was not correlated with tumor stage and patient's prognosis, the overexpression of CDH6 was positively associated with the expression of paired-box 8 (PAX8), a lineage-specific transcription factor. WebPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows …
A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and ...
WebFeb 1, 2004 · This is in line with what has been reported in ovarian cancer and renal carcinomas, where an overexpression of CDH6 is observed in tumor cells as compared with the normal counterpart [14,15]. WebCDH6 expression is increased specifically in renal cell carcinoma (RCC) and ovarian cancer (OVC). Therefore, CDH6 could be an attractive target for cancer therapy. We … shorts acostamento
Construction and Characterization of Cadherin 6 (CDH6
WebDec 8, 2024 · An in vivo study by Karthikeyan et al. confirmed that CDH6 was inhibited by mutant p53 in high-grade serous ovarian cancer, which suggests that CDH6 may be a biomarker for this condition 29. While ... WebJul 6, 2016 · Cadherin-6 (CDH6) is a type 2 cadherin, which drives EMT during embryonic development and it is aberrantly re-activated in cancer. We recently showed that CDH6 … WebJan 13, 2024 · Participants with ovarian cancer (OVC) or renal cell carcinoma (RCC) will receive an intravenous infusion of DS-6000a (starting dose 1.6 mg/kg). ... Has had prior treatment with other CDH6-targeted agents; Has had prior treatment with an ADC that consists of an exatecan derivative that is a topoisomerase I inhibitor (e.g., trastuzumab ... shorts accountants sheffield